| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In vivo release of protein-loaded microcapsules using in situ-forming hydrogels for a suppression of initial burst |
| 초록 |
In this work, we described the preparation of BSA-FITC-loaded microcapsules using in situ-forming hydrogels as controlled release system. BSA-FITC-loaded microcapsules were prepared using a mono-axial nozzle ultrasonic atomizer with a BSA-FITC core and a PLGA shell. Injectable formations were prepared by mixing BSA-FITC-loaded microcapsules and chitosan, Pluronic, or methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) solution. All injectable formations were subcutaneously injected into a rat. While monitoring in vivo BSA-FITC release, we found that the initial burst release of BSA-FITC retarded by in situ-forming hydrogels. In addition, the bioavailability of BSA-FITC from each formulation depended on the viscosities of the in situ-forming hydrogels. In conclusion, the injectable formulations in this work may provide numerous benefits as suppression of the initial burst release and a significantly extended duration of release from in vivo drug depot implants. |
| 저자 |
김다연, Waqas Iqbal, 손아름, 김은화, Prasamsha Panta, 김재호, 김문석
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| 소속 |
아주대 |
| 키워드 |
protein drug; microcapsules; hydrogels; in situ-forming
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| E-Mail |
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