| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
[생체재료] 미래기술을 위한 바이오 소재 혁신 |
| 제목 |
Photobiomodulation for improving therapeutic efficacy of adult stem cells using different light source |
| 초록 |
Poor therapeutic effect of stem cell therapy due to low cell viability and engraftment remained as critical problems to be solved. In this study, we have showed a new and optimized method that can enhance therapeutic angiogenesis in hADSCs using OLED. hADSCs with optiized OLED treatment significantly improved therapeutic angiogenesis in ischemic tissue by enhancing cellular functions such as angiogenic paracrine factor secretion, cell adhesion, and migration ability compared to normal hADSCs. Also OLED treated hADSCs showed significantly enhanced blood flow and limb salvage ratio with reduced fibrosis and tissue degeneration comapred to conventional cell injection method with reduced cell amount. Our method might suggest a new platform for future stem cell therapy related with ischemic disease. |
| 저자 |
방석호 |
| 소속 |
성균관대 |
| 키워드 |
Angiogenesis; Human adipose-derived stem cells; Ischemic diseases; OLED
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| E-Mail |
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