| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Intracellular delivery and activation of the genetically encoded photosensitizer KillerRed by quantum dots encapsulated in polymeric micelles |
| 초록 |
We have prepared polymeric micelle-encapsulating quantum dots (QDots) for delivering the optically activatable protein Killer Red (KR) as a plasmid to cancer cells. QDots absorb light at a lower wavelength and emit light at a higher wavelength in the cell cytoplasm, activating the expressed KR. Once activated, KR triggers the generation of reactive oxygen species (ROS). We prepared cadmium selenide (CdSe)/zinc sulphide (ZnS) QDots and evaluated their optical properties. Cell fate after exposure to blue light-emitting diode lighting was determined using apoptosis staining and a cell proliferation assay, confirming a suppression in proliferation and a reduction in metabolic activity. We determined that ROS generation contributed to cellular damage after treatment with PPP-QDot/KR nanoparticles and blue light exposure. |
| 저자 |
MUTHUNARAYANAN MUTHIAH1, 이상준1, 김원종2, 이용규3, 박인규1
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| 소속 |
1전남대, 2포항공과대, 3한국교통대 |
| 키워드 |
Photosensitizer Killer Red(KR); quantum dots(QDots); polymeric micells;
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| E-Mail |
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