| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
(콜로이드·계면화학) 다기능성 연성재료 및 응용 |
| 제목 |
Combination treatment comprising thermal therapy and chemoterapy using drug-contained gold nanorods |
| 초록 |
Combinatory treatment comprising thermal- and chemotherapy offers synergistic effects by inducing localized heat to targeted tumor sites and simultaneously delivering anticancer drugs to minimize systemic side effects and enhance the cytotoxic effect. In this study, we developed a novel platform for combining photothermal therapy and chemotherapy using drug-conjugated/contained gold nanorods (GNRs). Camptothecin (CPT) was chemically conjugated directly onto GNRs and to polymers on GNRs through hydrolytic ester bonding. Upon near-infrared (NIR) irradiation, localized heat from GNRs in target areas starts destroying tissues and cells via photothermal therapy and the elevated temperature accelerates hydrolysis of ester linkage, rapidly releasing drugs for chemotherapy. This combined NIR triggered thermal therapy and chemotherapy with drug-contained GNRs presents a synergistic effect that has high efficacy in in vitro tests, thus providing a robust platform for efficient cancer treatments. |
| 저자 |
박명환 |
| 소속 |
삼육대 |
| 키워드 |
gold nanorods; on-demand; drug delivery systems; Near-IR
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| E-Mail |
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