| 초록 |
We present a ‘crew-cut’ type micelle-like polymeric nanoparticles, which were prepared by the chelation of aquated cisplatin pharmacophore (PtII) at the block-copolymers of short poly(ethylene glycol) and elongated poly(acrylic acid). At high PtII-feeding ratio, 1H NMR analyses exhibited a significant hydrogen-bonding between PEG segments and the amine ligands of PtII, showing a highly increased electron density at the PEG shell in TEM image. Such hydrogen bonds can further increase the PtII-mediated interactions of PAA and PEG blocks, which can induce the aggregation of both blocks at the core, while decreasing the density of grafted PEG residues at the surface of nanoparticles. The characteristic colloidal structures related to such nanoparticles will be discussed. |
