| 학회 |
한국화학공학회 |
| 학술대회 |
2015년 가을 (10/21 ~ 10/23, 일산 KINTEX) |
| 권호 |
21권 2호, p.1408 |
| 발표분야 |
고분자 |
| 제목 |
Controlled Release Systems Based on Electrospun Nanofibers and Hydrogel |
| 초록 |
Recent advances in polymer and microgels have led to the development of materials that exhibit the ability to control release of encapsulated materials and undergo repair. In here, we developed a novel strategy to control the motion and drug release of self-healing microhydrogels together. Polylactic acid (PLA) nanofibers containing superparamagnetic nanoparticles (SPION) and a model compound were entrapped inside microhydrogels based on polyphenol-conjugated hyaluronic acid with the aim to develop carrier systems capable of self-healing and magnetic responsive delivery. The composite structures were prepared by a combination of electrospinning and spraying. The physically sprayed microparticles were ionically crosslinked with aqueous ferric ions, which enabled self-healing behavior. PLA-SPION entrapped microhydrogels were magnetic responsible because of the presence of PLA-SPION inside the microhydrogels. PLA-SPION entrapped microhydrogels showed a fast attachment in the presence of external magnetic force. Even after 10 min bath sonication the attached microhydrogels were not detached or dispersed. It concluded that the self-healing carrier system was successfully developed based on polyphenol-conjugated hyaluronic acids. |
| 저자 |
Kantappa Halake, 이종휘, Mallinath
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| 소속 |
Chung-Ang Univ. |
| 키워드 |
Hyaluronic acid; Spraying; Fe ions; Microgel; electrospinning
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| E-Mail |
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| 원문파일 |
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