| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표15분) |
| 제목 |
Antifreeze protein inspired gold colloids as facile and highly active artificial antifreeze material |
| 초록 |
Since the first discovery of antifreeze proteins (AFP) which control the growth of ice in the living organisms, lots of efforts have been made for transferring their functions to synthetic analogues. However, the function of the artificial antifreeze materials has been compromised due to the low activity and complicate synthetic route. In this work, we demonstrate that highly active artificial antifreeze material can be fabricated by simple conjugation of poly-threonine on gold colloids as an AFP mimic. By benefiting from rigid surfaces of gold colloids, ice binding sites (IBS) with large area are form and thereby ice recrystallization inhibition (IRI) activity was induced at nanomolar concentration. Additionally, when cubic gold colloids are used as scaffold, they exhibit IRI activity even at sub-nanomolar concentration which shed the insight on the effect of IBS area. Altogether, our work convincingly paves a facile design route toward high functioning artificial antifreeze material. |
| 저자 |
이재원1, 이상엽2, 임동권2, 안동준2, 이승우1
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| 소속 |
1성균관대, 2고려대 |
| 키워드 |
antifreeze protein mimics; ice recrystallization inhibitors; gold nanoparticle; ice; cryoprotectant
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| E-Mail |
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