| 초록 |
This study reports a microfluidic approach for fabricating biodegradable gelatin microparticles (GMPs) for embolization. We fabricated a monodisperse W/O emulsion as templates in a microfluidic device. The size of emulsion drops was regulated by controlling the flow rate of outer and inner fluids. We obtained the crosslinked GMPs in the range of 50-200 μm, while maintaining the particles' monodispersity. The conversion of the aqueous gelatin drops to the GMPs was conducted by injection of glutaraldehyde into the aqueous gelatin drops. We found that the degree of crosslinking of the GMPs essentially determined the degradation kinetics. Finally, we have demonstrated that the GMPs have great potentials as a biocompatible, biodegradable and nontoxic embolic material by showing their controlled phase degradation as well as controlled drug release. |
