| 학회 |
한국재료학회 |
| 학술대회 |
2018년 가을 (11/07 ~ 11/09, 여수 디오션리조트) |
| 권호 |
24권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Photocurable gelatin/bioceramic grafting material for bone regeneration |
| 초록 |
The effectiveness of autogenous bone graft for the treatment of bone defects has been proven in clinical practice. However, the amount available from donor sites is limited and invasive procedures are inevitable. Thus, alternative materials are required. Recently, synthetic bone graft materials (BGM) including hydroxyapatite (HA) and beta tricalcium phosphate (β-TCP) have been studied actively. Amongst these, β-TCP is completely absorbed by regeneration of new bone after transplantation. We applied gelatin, an inducible protein obtained from collagen, into the β-TCP. Gelatin is widely used in tissue engineering field due to having biodegradability and high biocompatibility. In this study, we synthesized gelatin-methacrylate (GelMA) hydrogels and produced a gelatin-methacrylate/β-TCP composite (Gel-B). Gel-B was measured by using a rheometer and a tensile strength tester for characterization of physical properties. It was then analyzed for biocompatibility and osteogenic differentiation using human adipose derived stem cells. In addition, the bone regeneration effect of Gel-B was analyzed in an animal model. As a result, Gel-B was found to have a higher strength than β-TCP and GelMA alone. It also showed a relatively high bone differentiation ability and provided for excellent bone regeneration. It is also confirmed that injection can be performed during the procedure and the gel shape can be maintained after injection. These results suggest that Gel-B can be used as a BGM, and Gel-B is expected to induce more efficient bone regeneration by loading stem cells or activation factors into GelMA hydrogels. |
| 저자 |
Donghyun Lee1, Ho-Jin Moon2, Jae Seo Lee3, Ha Ram Nah1, Il Keun Kwon2
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| 소속 |
1Department of Dental materials, 2School of Dentistry, 3Kyung Hee Univ. |
| 키워드 |
β-tricalcium phosphate; gelatin; bone regeneration; bone graft materials; hydrogels
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| E-Mail |
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