| 초록 |
We present a novel method for the synthesis of monodisperse gelatin microbeads in a microfluidic system. Aqueous gelatin droplets were continuously produced in an immiscible continuous oil fluid. By cooling the droplets, the aqueous gelatin droplets solidified into hydrogel microbeads. The produced gelatin microbeads have a high monodispersity and fast response to environmental temperature. In addition, the size of the prepared microbeads can be manipulated by altering the flow rate of the continuous phase or aqueous phase, and the physical strength of the gelatin microbeads can be controlled by simply changing the gelatin concentration. Furthermore, this approach enables the preparation of monodisperse microbeads with the ability to exhibit different thermosensitivities and encapsulate colloidal particles under mild conditions, which demonstrate sequential release of the desired encapsulants according to the responsive temperature. |
