| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
대학원생 구두발표(토론II): 생분해성 고분자 기반 재생/진단/전달체 연구 |
| 제목 |
PD-L1-Targeted Doxorubicin Delivery Using Glycol Chitosan Nanoparticles for Synergistic Cancer Chemoimmunotherapy |
| 초록 |
Although chemotherapy drugs can elicit anti-tumor immune responses by releasing tumor antigens via immunogenic cell death (ICD) to tumor cells, immunosuppressive tumor microenvironment by an immune checkpoint of tumor cells remains a significant obstacle for improving therapeutic efficacy. Herein, we developed PD-L1-binding peptide-conjugated glycol chitosan nanoparticles (pPCNPs) to serve as a targeted delivery platform for the delivery of doxorubicin (DOX) to PD-L1-expressed tumor cells. DOX-loaded pPCNPs (DOX-pPCNPs) showed higher internalization and ICD in CT-26 tumor cells via receptor-mediated endocytosis than DOX-loaded CNPs (DOX-CNPs). In vivo results showed that pPCNPs effectively delivered DOX to PD-L1-expressed CT-26 tumor tissue compared to CNPs and free DOX, significantly inhibiting tumor growth by using both ICD and PD-L1 blockade effects. Based on these results, we expect that pPCNPs could provide a promising strategy for effective chemoimmunotherapy of tumors. |
| 저자 |
이재완1, 김광명1, 윤홍열2, 송수경2, 양수아2
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| 소속 |
1KU-KIST 융합대, 2한국과학기술(연) |
| 키워드 |
PD-L1; Doxorubicin Delivery; Glycol Chitosan Nanoparticles; Cancer Chemoimmunotherapy
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| E-Mail |
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