| 초록 |
Decoding the genome-wide regulatory networks in response to environmental stresses is prerequisite to rationally design microbes surviving against stresses such as metal iron depletion, oxidative stress, low pH stress, and osmotic stress. However, the full regulatory potential of microbes remains undefined. Here, we comprehensively reconstructed transcriptional regulatory networks of several transcription factors related to iron depletion, oxidative stress, low pH stress, and osmotic stress in Escherichia coli by using genome-wide measurements. Integrative data analysis revealed that each transcription factor exhibits complex role in many fundamental cellular processes to coordinately respond to iron starvation stress, low pH stress, oxidative stress, and osmotic stress as well. These types of new knowledge can be further utilized to find proper engineering targets to improve cellular tolerance towards these stresses. |
