| 초록 |
3-dimensional and patterned scaffold fabrication has been a challenge for the tissue engineering that can induce the functional recovery of tissues, for example, directional growth of axons for neural engineering approaches. Moreover, the patterned fibrous structure of tissue engineering scaffolds are highly valuable for spatial regulation of cellular. To achieve the goals, patterned fiber bundled scaffolds which were comprised with multiple nanofibers were fabricated by salt-induced bundled electrospinning (SiEP scaffolds) and the neural cellular responses were evaluated. The SiEP scaffolds revealed distinctive morphological and topographical characteristics, such as multi-complexed internal structures with nano- and micro- fibers, rough surfaces, and soft mechanical properties. SiEP scaffolds resulted in highly robust axon extensions along the patterned bundles. Finally, the neuronal differentiation of hNSCs were boosted on the rough grooves of the SiEP bundles. |
