| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-나노 |
| 제목 | A Remarkable Enhancement by 3D hierarchical Nanostructure in a Label-free SERS Sensor for the Detection of Urinary Exosomal miRNA |
| 초록 | In prostate cancer (PC), tumor-derived urinary exosomal miRNAs have become emerging biomarkers for early diagnosis and prognosis of PC, Herein, we present a label-free surface-enhanced Raman scattering (SERS)-based sensor for the detection of urinary exosomal miRNAs from PC clinical samples. Label-free and ultrasensitive miRNA detection with single nucleotide-level specificity was achieved by strong amplification of SERS signals which are specific to each miRNA in three-dimensional hierarchical plasmonic nanoarchitecture. This plasmonic nanostructure is constructed by self-assembly between head-flocked gold nanopillar and target-complementary DNA probes-conjugated gold nanoparticles, which creates multiple SERS hotspots in the nano-gaps between nanopillars and nanoparticles. The SERS-based sensor achieved an attomolar detection limit, abroad dynamic range (10 aM to 100 nM), and multiplex detection of target urinrary exosomal miRNAs without any labeling or amplification steps. |
| 저자 | 김상기, 심상준 |
| 소속 | 고려대 |
| 키워드 | SERS; Urinary exosomal microRNA |
