| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.175 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | MPEG-PLGA Diblock Copolymer as 5-FU Drug Carriers |
| 초록 | Implantable wafer is one of the candidates to achieve long term drug release. Therefore, much attention has been given to the development of sustained drug delivery system based on biodegradable poly(lactic-co-glycolic acid) (PLGA). In this study, we focused on PLGA modified by methoxy-polyethyleneglycol (MPEG) to control release pattern of 5-FU as anti-cancer drug from the implantable biodegradable wafers. MPEG-PLGA diblock copolymers were prepared by ring-opening polymerization for a mixture of glycolide (GA) and lactide (LA) monomer with different mole ratios in the presence of MPEG as an initiator. The 5-FU loaded wafers were fabricated by direct compression method after freeze milling to disperse uniformly 5-FU into various MPEG-PLGA diblock copolymers. The release of 5-FU from wafer fabricated by various diblock copolymer was examined. In conclusion, we confirmed that the release pattern of 5-FU can be controlled by hydrophilic-hydrophobic balance between MPEG and PLGA. Acknowledgement: This work was supported by KMOCIE (10006921). |
| 저자 | 김수인1, 서광수1, 김문석2, 조선행2, 강길선1, 이종문1, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | MPEG-PLGA diblock copolymer; implantable wafers; sustained drug release |
