| 초록 |
Various biomaterials delivering inorganic ions have been spotlighted in tissue engineering and regenerative medicine. Among the reported inorganic ions, it is well known that zinc ion (Zn2+) regulates the cellular function and facilitates wound healing. While various Zn-based biomaterials have been extensively developed, they have some limitations, including complex procedures and burst ion release. Herein, we develop Zn2+-releasing in situ hydrogels via zinc peroxide (ZnO2)-mediated crosslinking reactions. Our hydrogels show controllable physicochemical properties and sustained Zn2+-release behavior depending on the ZnO2 concentrations (0.125-0.5 wt%) for 14 days. Notably, the hydrogels improve the wound healing process, such as cell proliferation, vascular recruitment, hair follicle development, and collagen synthesis. In conclusion, we suggest that our bioactive hydrogels have great potential for tissue regeneration. |
