| 초록 |
A novel thermosensitive chitosan copolymer was prepared by grafting of Pluronic (PEG-b-PPG-b-PEG triblock copolymer) onto chitosan using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide(EDC) and N-hydroxysuccinimide(NHS). The physicochemical properties of the resulting chitosan copolymer were characterized by FT-IR, 1 H-NMR, and solubility test. Sol-gel transition behavior was investigated by the cloud point measurement of the chitosan-g-Pluronic aqueous solution. The gelling temperature was examined by the vial tilting method. Chitosan-g-Pluronic copolymers were successfully prepared and they formed thermally reversible hydrogel, which exhibits a lower critical solution temperature(LCST) around 34℃ in aqueous solution. These results suggest that chitosan-g-Pluronic copolymer would be useful in biomedical and pharmaceutical applications as an injectable material for cell and drug delivery. |
