| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
A Safe and Effective Injectable Formulation of a Novel Prodrug Blend Thermogel for Inner Ear Drug Delivery |
| 초록 |
Currently,methods of drug delivery into the inner ear via intratympanic administrationhave unmet the requirements for efficacy and safety in clinical studies. In this study, we prepared a novel prodrug blendthermogel with high drug loading and controlled release capacities by physicalmixing of hexanoyl glycol chitosan (HGC) as a thermogel component anddexamethasone conjugated glycol chitosan (GC-DEX) as a prodrug component. Theblend thermogels with different composition ratios of HGC to GC-DEX wereprepared and evaluated for injectable formulation application. The blend thermogelsdemonstrated promising thermogelling and rheological properties (shear-thinningand high viscosity recovery) for injectable formulation application and also aprolonged release ability compared to free DEX and HGC hydrogel formulations. Consequently,our prodrug blend thermogel system could be useful as an effective injectable formulationfor intratympanic administration. |
| 저자 |
Le Thi Phuc1, 서은영2, 허강무1
|
| 소속 |
1충남대, 2추남대 |
| 키워드 |
Thermogels; prodrug; drug delivery; intratympanic injection; inner delivery system
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| E-Mail |
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