| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Sustained Release of Growth Factor from Leaf-Stacked Structure Microparticles for Intervertebral Disc Regeneration |
| 초록 |
It has been reported that 80% of the human population experiences low back pain at least once in their lifetime. Major cause of the low back pain is understood by intervertebral disc degeneration (IDD) which caused by dehydration of nucleus pulposus. The nucleus pulposus is consist of proteoglycan-rich extracellular matrix and nucleus pulposus cells with chondrocytic phenotype. In recent years, human bone marrow mesenchymal stem cells (hBMSCs) which can be differentiated in multi-lineage have been widely adapted to reconstruct the nucleus pulposus and reduce IDD. In this study, we fabricated a growth factor-loaded microparticle with leaf-stacked structure which can allow sustained release of the growth factor. The hBMSCs were also seeded on the microparticle for the effective treatment of IDD. The growth factor release behavior, chondrogenic differentiation of the hBMSCs, and intervertebral disc regeneration using beagle dog animal model were investigated. |
| 저자 |
김민지1, 이재훈2, 김준수2, 이진호3, 오세행1
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| 소속 |
1단국대, 2경상대, 3한남대 |
| 키워드 |
stem cell; intervertebral disc; microparticle; growth factor
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| E-Mail |
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