| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Development of PLLA electrospun nanofibers immobilized with collagen type Ⅳ for enhanced endothelialization |
| 초록 |
The inner layer of the blood vessel is made up of endothelium and basement membrane, which closely interact with each other. In particular, basement membrane is mainly composed of laminin and collagen type Ⅳ which regulate endothelial cell adhesion, proliferation and differentiation. The current artificial vascular grafts exhibit many problems such as restenosis and hyperplasia, and thus the development of vascular grafts that are able enhance endothelialization is important. Many studies such as electrospinning and surface modifications have been underway. However, successful mimicry of natural blood vessel has still not been achieved. In this study, we immobilized collagen type Ⅳ onto the electrospun-PLLA nanofiber, to mimic vascular basement membrane. Both acrylic acid grafting through the gamma-ray was used to immobilize collagen type Ⅳ. Immobilized collagen type Ⅳ increased endothelial cell adhesion and proliferation. |
| 저자 |
허윤회1, 이유빈1, 신영민2, 임윤묵2, 신흥수1
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| 소속 |
1한양대, 2한국원자력(연) |
| 키워드 |
electrospinning; collagen type Ⅳ; endothelialization
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| E-Mail |
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