| 초록 |
Lipid is a short amphiphilic molecule derived from our body. Depending on its molecular shape, it can self-assemble into various phases spanning from simple bilayer (lamellar) to inverse hexagonal and bicontinuous cubic structures. We commonly perceive that lipid in our body forms a simple bilayer structure (such as in cells), but there are non-lamellar phases observed especially during membrane fusion processes. X-ray scattering and biological studies revealed that such non-lamellar structures promote the membrane fusion process. Inspired by the favored fusion process of non-lamellar structures, we have been engineering lipid membranes for various biomedical applications. In this talk, I will discuss lipid membrane engineering strategies in the context of 1) siRNA delivery, 2) super-swelled lyotropic single crystals, and 3) biosensor applications. |
