| 초록 |
Photocrosslinkable biodegradable polymers have emerged as a new class of biomaterials in tissue adhesion and drug delivery. In part 1 of my talk, I will present in situ photocrosslinkable hyaluronic acid (HA)-based tissue adhesives, providing tunable mechanical properties and firm tissue adhesion under wet and dynamic conditions. Depending on the degree of photocrosslinkable groups, mechanical and adhesive properties were improved. In part 2, I will present a radioactive HA hydrogel microparticles, which can be used for local radiotherapy with minimal off-target biodistribution. The radioactive HA microgels exhibited a prolonged radioactivity kinetics similar to the natural decay of radioisotope, thereby providing long-term and predictable radioactivity. Moreover, using a rat model, we further confirmed the local retention of photocrosslinked HA microgels around the injected site and their high biocompatibility throughout the application period. |
