| 초록 |
Hydrophilic polysaccharides have been used as films, nanoparticles, and scaffolds in a wide range of biomedical and biological application. In this paper, sodium alginate (SA)/chitosan (CS)/polyacrylamide (PAM) based IPN-structured hydrogels has been fabricated through polyelectrolyte complex (PEC) (in situ formation using glucuronic acid delta-galactone as acidifying agent) followed by free radical polymerization using N,N’-methylene-bis-acrylamide as crosslinker. The structure and interactions IPN-structured hydrogels were confirmed by FTIR, XRD, and XPS techniques. PEC has greatly influenced the swelling, porosity, porous structure and mechanical properties of hydrogels. Moreover, hydrogels also showed bio-mineralization capacity in SBF solutions. Finally, the hydrogels showed good cell adhesion, and proliferation property with human osteoblasts (hFOB 1.19) cells proved that the developed hydrogels have the potential for bone tissue engineering applications. |
