| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
기능성고분자－막분리용 고분자 |
| 제목 |
Preparation of Amine Bridged Periodic Mesoporous Organosilicas and Applications to the pH-sensitive Nanovalves for Drug Delivery |
| 초록 |
Amine bridged periodic mesoporous organosilicas(PMO) have been successfully prepared using bis(3-(trimethoxysilyl)propyl)amine and tetraethoxy orthosilicate as co-precursors. The PMOs possess mesopores of 2-4 nm with the overall particle size of 50~100 nm. The particle sizes are suitable for using drug delivery system. From zeta potential data, the bridged amine PMO particles have positive charge due to bridged amine moiety in frameworks. Various properties of these PMOs were characterized by transmission electron microscopy (TEM), BET, X-ray photoelectron spectroscopy (XPS), elemental analysis, and etc. To investigate nanovalve performances of the PMOs, we attached N-phenylaminomethyltriethoxysilane(PhAMTES) to the PMO surface and loaded Hoechst into the pore and capped with β-cyclodextrin. The amine bridged PMO nanovalves successfully released Hoechst at pH 6 in water. |
| 저자 |
홍상현1, 박성수1, Melissa Russell2, Jeffrey I. Zink3, 하창식2
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| 소속 |
1부산대, 2Department of Chemistry and Biochemistry, 3Univ. of California Los Angeles |
| 키워드 |
mesoporous organosilicas; PMO; nanovalves; pH-sensitive
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| E-Mail |
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