| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Metal oxide nanoparticle stabilized by pH sensitive PEO-based block copolymersContaining sulfadrug moiety. |
| 초록 |
Synthesis of water-soluble block copolymers exhibiting pH-responsive phase transition behaviors was carried out via transformation reaction. n-Butyllithium-initiated ring-opening polymerization of ethylene oxide was first performed in the mixture of benzene and DMSO at 40℃, followed by chain-end functionalization using proper electrophiles. Among them, the PEO-based macroinitiator was converted into RAFT (reversible addition fragmentation chain transfer) agent carrying a dithioester group. Using the RAFT agent and AIBN, RAFT radical polymerization of sulfadimethoxinyl methacrylamide (SDMA) and N-phenylmaleimide (N-PMI) was successfully performed in toluene at 90℃ for 6 h. Deimidation of N-PMI unit was carried out in the resulting poly(ethylene oxide) -b- poly(SDMA -co- Mac). We also prepared triblock copolymer, PEO -b- PSDMA -b- PMAc. The resulting pH sensitive block copolymers were used as polymer stabilizers for preparation of metal oxide nanoparticles such as Fe3O4. |
| 저자 |
김태환1, 김근석1, 이정화1, 조영준1, 김보리2, 김훈태3, 김정안1
|
| 소속 |
1경희대, 2KIST, 3서강대 |
| 키워드 |
PEO; PEG; N-PMI; SDMA; Sulfa drug; n-BuLi; t-BuOK; RAFT; AIBN
|
| E-Mail |
|
