| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
(콜로이드계면화학) 최신 콜로이드 기반 융합 기술 |
| 제목 |
The effect of multivalent cations on paclitaxel-stabilized microtubule assembly, disassembly, and structure |
| 초록 |
We focus on the effects of multivalent cations, and separately, of microtubule-associated protein (MAP) Tau, on microtubule (MT) ordering (bundling), MT disassembly, and MT structure. Counter-ion directed bundling of paclitaxel-stabilized MTs is a model electrostatic system, which parallels efforts to understand MT bundling by intrinsically disordered proteins expressed in neurons. We describe studies, which reveal an unexpected transition from tightly spaced MT bundles to loose bundles consisting of strings of MTs as the valence of the cationic counter-ion decreases from Z=3 to Z=2. In a more biologically related system we review synchrotron small angle x-ray scattering (SAXS) studies on the effect of the Tau on the structure of paclitaxel-stabilized MTs. |
| 저자 |
송채연1, Cyrus R. Safinya2, Peter J. Chung3, Youli Li2, Kai K. Ewert3, Myung Chul Choi2
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| 소속 |
1아모레퍼시픽, 2Univ. of California, 3Santa Barbara |
| 키워드 |
Microtubules; paclitaxel
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| E-Mail |
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