| 초록 |
We investigated the surface functionalization of periodic arrays of gold nanoholes using thiol-teminated methoxy polyethylene(glycol) (mPEG-SH) polymers of varying molecular weights. By controlling the geometrical dimensions of the nanoholes and selecting an appropriate mPEG-SH, it was possible to selectively capture individuals sub-100 nm diameter nanoparticles, i.e., model virus particles, in the nanoholes. Using the nanohole platform, we conducted nanoplasmonic biosensing experiments in order to study particle adsorption and peptide-induced rupture. Compared to a non-functionalized nanohole sensing platform, the polymer-fuctionalized sensing platform demonstrated superior sensing performance for detecting particle rupture events. Our findings demonstrate the merits of functionalizing metallic nanoholes with polymer coatings in order to control the immobilization of biological nanoparticles such as virus particles and exosomes for biomacromolecular interaction analysis. |
