| 초록 |
Micelle formulations that remain relatively stable in vivo enable improved biodistribution, and tumor targeting through the enhanced permeability and retention (EPR) effect. We recently reported a Pluronic F-127 polymeric micelle that facilitates tumor accumulation of a near-infrared (NIR) dye, indocyanine green (ICG), in xenograft mouse models following intravenous injection. However, Pluornic F-127 micelles are not stable at room temperature, making micelle preparation and handling challenging. In this work, we report mixed micelles encapsulating ICG that were formed from PEO-PHB-PEO (poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) and Pluronic F-127 block copolymers. Advantages of the mixed micelle formulations over pure PEO-PHB-PEO or PF-127 micelles include facile formulation at room temperature, filamentous structures, reduced plasma clearance rate, and increased passive tumor targeting. These formulations are therefore promising for tumor-targeted imaging and drug delivery. |
