| 초록 |
The emerging trend in designing advanced hydrogels is to create a bioactive matrix stimulating the native tissues by physicochemical and biological stimuli. Among these factors, hyperoxia (over 21% pO2) has been attracted much attention due to its facilitating wound healing ability. While various peroxides with catalase have been used as oxygen (O2)-generating agents, it still has cytotoxicity issues, such as excessive oxidative stress of hydrogen peroxide or catalase-mediated cellular signaling suppression. Herein, we present a catalase-immobilized syringe (Oxyringe) as a new type of O2-supplying platform. The Oxyringe creates cytocompatible O2-releasing hydrogels, showing O2 release up to 47.9% pO2 in vivo. Furthermore, this hydrogel boosts the initial macrophage recruitment, cell proliferation, and neovascularization, expediting the tensile strength of regenerated skin tissue in vivo. In sum, Oxyringe has excellent potential as advanced O2-supplying systems for tissue regeneration. |
