| 초록 |
Oxygen (O2) plays a critical role as a signaling molecule regulating cellular activities. In particular, hyperbaric O2 has been demonstrated to facilitate wound healing processes via transient oxidative stress. Herein, we report a hyperbaric O2-generating (HOG) hydrogel formed via calcium peroxide-mediated oxidative crosslinking reaction. We demonstrate that the HOG hydrogel could rapidly generate molecular O2 up to the hyperbaric levels (over 90% pO2) and release O2 from hydrogel matrices in a sustained manner (for up to 12 days). The HOG hydrogel enhances the cell proliferative activities of human dermal fibroblasts and endothelial cells in vitro and facilitates wound healing with enhanced tissue infiltration and improved vascular recruitment in vivo. We suggest that our HOG hydrogels have great potential as advanced O2-delivering matrices for the treatment of wound healing, vascular disorders as well as tissue regenerative medicine. |
