| 초록 |
The aim of this study is to overcome solubility of poorly water soluble drugs, we prepared solid dispersion containing particle of celecoxib for improvement of dissolution property by using spray dryer. This solid dispersions was formulated to improvement of dissolution using AEA (poly vinylacetaldiethylaminoacetate) and PVP (poly vinyl pyrrolidone). Characterization of celecoxib solid dispersion was analyzed by SEM, DSC, XRD and FT-IR. DSC and XRD were used to analyze the amorphous of solid dispersions. FT-IR was used to analyze the salt formation by hydrogen bond between celecoxib, AEA and PVP. The in vitro release behavior of solid dispersion presented in simulated gastric juice (pH 1.2). The dissolution rate of celecoxib was dramatically higher than commercial drug (Celebrexc®). This studies suggest that this solid dispersion system improved the bioavailability of poorly water-soluble drug, such as celecoxib. This research was supported by WCU (R31-20029). |
