| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Ternary complexes of gene, peptide, and chitosan for co-delivery systems |
| 초록 |
The aim of this study was to co-deliver gene and peptide for synergetic action against tumor. The ternary complexes of gene, peptide, and chitosan was prepared by electrostatic interaction in aqueous solution. The ternary complexes was confirmed by electrophoresis. The particle size of them was evaluated by DLS. The result of tranfection showed that they was effectively delivered into cancer cell. The co-delivered gene and peptide showed that gene had a RNA-silencing action by shRNA and peptide inhibited tumor growth by mitochondrial apoptosis. This system will contribute to develop antibiotic peptide-delivery system. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education. Science and Technology (NRF-2012R1A2A2A01014898). |
| 저자 |
정경원, 김준호, 김태훈, 장재영, 박성철, 최창용, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
gene; peptide; chitosan
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| E-Mail |
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