| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Synthesis of poly(ethylene oxide) -b- poly(N-phenyl maleimide) and its application for drug delivery system |
| 초록 |
A variety of polymerizations of N-phenylmaleimide(N-PMI) via several mechanisms have been reported by several groups. Especially, anionic polymerization of N-phenylmaleimide (N-PMI) was carried out in the mixture of benzene/THF/DMSO at room temperature using polymeric alkoxide as an initiator. The polymeric alkoxide was obtained from n-butyllithium-initiated ring-opening polymerization of ethylene oxide (EO) in the presence of potassium tert-butoxide in the mixture of benzene/DMSO at 35℃. Some fraction of the poly(N-PMI) fragment was reported to be soluble in tetrahydrofuran (THF), dimethylsulfoxide (DMSO), dimethylformamide (DMF), and dichloromethane depending on the isomeric structure. The THF-soluble N-PMI fragment was deimidized in DMF or DMSO at 120℃ using hydrazine monohydrate. The results for these experiments will be presented in this study |
| 저자 |
김진흥1, 조영준1, 남주현1, 김형철1, 김훈태2, 김정안1
|
| 소속 |
1경희대, 2서강대 |
| 키워드 |
poly(ethylene oxide); poly(N-phenylmaleimide); drug delivery system
|
| E-Mail |
|
