| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
휴먼인터페이스 의료용 고분자재료 (의료용 고분자 부문위원회) |
| 제목 |
Polycation-based self-assembled delivery complex: a new way of heparin-mediated growth factor delivery for therapeutics |
| 초록 |
A series of previous in vivo studies demonstrated that self-assembled polymeric complex using polycations effectively deliver the heparin-binding growth factors. Poly(ethylene argininylaspartate diglyceride) (PEAD) that is based on arginine, aspartic acid, has been investigated for the development of the self-assembeled delivery complex. A basic principle of polycation-mediated growth factor delivery complex is that first, binding growth factors with heparin-binding affinity with heparin. Then, positively charged polycations will simply interact with an excess negative charge of heparin/growth factor complex to create spherical droplets in aqueous solution. The release of cargo protein depends on the degradation of polycation polymer backbone and dissociation between heparin and growth factor. A series of in vivo studies will be introduced to demonstrate the in vivo functionality of PEAD-based growth factor delivery complex. |
| 저자 |
김교범 |
| 소속 |
인천대 |
| 키워드 |
Polycation; self-assembly; growth factor delivery
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| E-Mail |
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