| 초록 |
Polymeric self-assemblies, spherical, cylindrical micelles together with vesicles, have attracted tremendous interests from many researchers in the field of drug delivery system. Compared to low molecular weight surfactant, they are more stable and shows less fast dissociation. Especially, self-assemblies with oxidation, pH and thermal sensitivity from diblock copolymer were reported for controlled assembling and entrapment of therapeutic agents. Not only enhanced stability, these assemblies provide also benefits of less toxic drug-loading method due to a stimuli-induced assembling into assemblied structure with various morphologies. In this study, thermo-sensitive self-assemblies from biodegradable copolymer are reported and the physicochemical properties of self-assemblies were investigated in terms of size, critical aggregation concentration, and thermal sensitivity. |
