| 학회 | 한국공업화학회 |
| 학술대회 | 2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 | 19권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Preparation of Phosphonated Low-Molecular-Weight Chitosan Derivative as Coating Material to Improve Cell Adhesion on Titanium Surface |
| 초록 | Phosphonated low-molecular-weight chitosan (P-LMC) was prepared for improving cell adhesion on titanium surfaces. P-LMC was prepared by introducing a phosphonate group from 4-phosphonobutyric acid to low-molecular-weight chitosan. Introduction of the phosphonate group was confirmed by 31P-NMR. Characterization of titanium surfaces treated with P-LMC was by XPS and water contact angle. Prepared P-LMC should have no toxicity for medical applications. Cytotoxicity was tested in WST-8 assays using the C2C12 cell line. Improvements in cell adhesion on treated titanium surfaces were observed by microscopy and the number of attached cells was counted using a hemocytometer. Titanium surfaces with P-LMC had positive effects on cell adhesion. In conclusion, it is considered that P-LMC could be applied as titanium coating material. Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and future Planning (No. NRF-2014R1A2A1A11052623) |
| 저자 | 김은혜, 정진홍, 한가득, 손태일 |
| 소속 | 중앙대 |
| 키워드 | reforming of titanium surface; cell adhesion; phosphonated chitosan |
