화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2008년 가을 (10/09 ~ 10/10, 일산킨텍스)
권호 33권 2호
발표분야 의료용 고분자 부문위원회
제목 Injectable supramolecular hydrogel based on chitosan and poly(pseudo)rotaxane by enzymatic trigger
초록 In recent years, supramolecular hydrogels have attracted much attention because of their potential applications in biotechnology and bioengineering. Herein, on the basis of the synthesis of poly(pseudorotaxane)-tyramine-succinate ester (PPRX-TSa), poly(rotaxane)-succinate ester (PRx-Sa) and 4-hydroxyl phenyl acetamide (CHPA), the supramolecular hydrogels were fabricated under physiological condition by enzymatic crosslinking with horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The structures of supramolecules and modified chitosan were characterized by 1H-NMR spectra. The PPRx-CHPA and PRx-CHPA in aqueous solution were rapidly formed the hydrogel around 10 and 20 seconds respectively. The physicochemical properties of the hydrogel were measured on the difference of the HRP content and H2O2 molar ratio. Obtained results suggest that enzymatic triggered supramolecular hydrogels could be applied as an injectable material in the tissue engineering and drug delivery.
저자 , 정윤기, 박경민, 박기동
소속 아주대
키워드 Injectable hydrogel; poly(pseudo)rotexane; enzymatic reaction
E-Mail