초록 |
Pore formation and control of their sizes in hydrogels are essential in tissue engineering, microfluidics, and soft actuators. For the creation of several hundred-micrometer pores, many approaches such as freeze-drying, gas foaming, electrospinning, etc. have been developed. But the control of pore sizes between sub and few micrometers has rarely been studied, though there is a need for porous micro-scale objects. Besides, most of pore formation methods developed so far require specific fabrication tools or are not compatible with micro-fabrication methods. Here, we suggest a simple way to control pore sizes between sub and few micrometer scale, consistent with the conventional photolithography technique. Photo-crosslinkable hydrogel contains benzophenone is selectively crosslinked in the composite film with polystyrene, and pores are successfully formed after removal of polystyrene. The method does not generate any additional step in the photolithography process. |