| 학회 | 한국화학공학회 |
| 학술대회 | 2017년 봄 (04/26 ~ 04/28, ICC 제주) |
| 권호 | 23권 1호, p.1357 |
| 발표분야 | 신진연구자 심포지엄 |
| 제목 | Construction of RNA-Nanoparticle Hybrid Nanostructure for Bioelectronic Device and Biosensor Application |
| 초록 | Conventionally, RNA nanotechnology has been investigated for cancer treatment, gene delivery and viral infection. Recently, RNA nanotechnology has been extended to application fields such as bioelectronics and biosensors because of catalytic functionality, flexibility of structure and thermodynamic stability. In this study, we developed the selective conjugation method of RNA-nanoparticles for bioelectronic device and biosensor applications. The selective-functionalization of gold nanoparticle onto pRNA structure was achieved utilizing the resin-recognizing RNA aptamer. Moreover, to determine the binding number of pRNA onto nanoparticle, the single molecule photobleaching (SMPB) experiment was conducted TIRF microscopy. Based on this technique, pRNA-quantum dot hybrid and pRNA-gold nanoparticle hybrid were prepared respectively. The RNA-nanoparticle hybrid can be applied to various applications such asbioelectronics, biosensors and biomedical device. References 1. Taek Lee et al, (2015), ACS NANO, 9, 6675. 2. Hui Li, Taek Lee et al, (2015), Nano Today, 10, 631. |
| 저자 | 이 택1, Peixuan Guo2, 최정우3 |
| 소속 | 1광운대, 2College of Pharmacy, 3Ohio State Univ. |
| 키워드 | RNA Nanotechnology; pRNA-Nanoparticle; Biosensor; Bioelectronic Device |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
