| 초록 |
The root cause of many diseases and obesity in the human body is reactive oxygen species (ROS). To solve these problem, anti-oxidant was used as ROS protection agent, which has a potential ability such as immune effect, anti-inflammatory, anti-oxide, anti-cancer effective and low toxic. However, it has a problem such as very a low bioavailability in body and high toxicity. These for reason, we developed to antioxidant-encapsulated chitosan microsphere (AECM) by using spray dry method. Chemical structure of AECM was analyzed by 1H-NMR and FT-IR. Also, content and encapsulation efficiency of antioxidant from AECM were analyzed by UV-Vis spectrophotometer. Additionally, morphological property and particle size of AECM were analyzed by SEM, which showed that had a spherical shape and 2 ~ 8 ㎛ size. In addition, its cytotoxicity was evaluated by MTT assay. These results suggest that AECM can effectively remove to ROS with low toxicity and increased bioavailability. (NRF-2016H1D5A1910499). |
