| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 가을 (10/26 ~ 10/28, 송도컨벤시아) |
| 권호 |
17권 2호, p.1794 |
| 발표분야 |
재료 |
| 제목 |
Tip-streaming Generation of Sub-micrometer-sized Emulsions in 3D Flow Focusing Microfluidic Devices |
| 초록 |
Droplet-based microfluidics have attracted extensive interest because of their potential uses in high-throughput screening for drug discovery or toxicology, and materials synthesis. Previously, monodisperse emulsions were successfully produced in T-junction or flow-focusing geometry. However, their minimum achievable size and volume were generally limited to a few micrometer and femtoliter, respectively. In the present study, we have introduced a three-dimensional (3-D) flow-focusing design optimized for stable tip-streaming mode production of sub-micrometer-sized emulsion droplets. Our 3-D flow-focusing channel consists of square waveform geometry with its side view and zigzag path for more drag force in dispersed phase channel. Therefore, the hydraulic resistance toward the direction of water flow inlet became much higher than the direction of downstream flow. As a result, the fluctuation-induced retraction of Taylor-cone for tip-streaming mode was suppressed significantly. We investigated the experimental condition for establishing a stable tip-steaming mode and producing submicron-sized water-in-oil emulsion with a narrow distribution. |
| 저자 |
정웅찬1, 이기라2, 임종민1, 양승만1, 최재훈1, 김종훈3, 김종득3, 이개항4
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| 소속 |
1한국과학기술원 / 광자유체집적소자연구단, 2충북대, 3한국과학기술원, 4한국기초과학지원(연) |
| 키워드 |
microfluidics; submicron emulsions; drug delivery
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
