| 초록 |
Supramolecular hydrogels based on host-guest interaction that show shear-thinning and self-healing properties has been studied for biomedical applications such as 3D bio-ink, drug delivery carriers. Particularly, β-cyclodextrin and adamantane show high binding and reversible interactions, resulting in in situ hydrogel formation. However, these structures have relatively weak mechanical strength. In this study, we developed a shear-thinning hydrogel using poly(β-CD) and Tetronic-adamantane (Tet-Ada), to improve the mechanical strength at 37℃ due to the thermosensitive nature of Tetronic. The viscosity of the hydrogel, according to the shear rate, can be controlled by varying the polymer concentrations. The cyclic deformation test showed that this hydrogel exhibited shear-thinning behaviors, rapid recovery properties. In conclusion, the poly(β-CD)/Tet-Ada hydrogels show great potential for biomedical applications. |
