| 학회 |
한국화학공학회 |
| 학술대회 |
2004년 가을 (10/29 ~ 10/30, 호서대학교(아산캠퍼스)) |
| 권호 |
10권 2호, p.2059 |
| 발표분야 |
재료 |
| 제목 |
Real-time Atomic Force Microscopy Investigation of Calcium Oxalate Crystal Growth |
| 초록 |
The formation of calcium oxalate monohydrate (COM), which is regulated by urinary (macro)molecules, is an important issue in kidney stone formation. These organic (macro)molecules in urine can act as inhibitors of the stone formation but the microscopic origin underlying these phenomena remains ambiguous. In this study, the growth inhibition of COM microcrystals by synthetic polypeptides, poly(acrylate), poly(aspartate), and poly(glutamate), is investigated in microscopic level using real-time atomic force microscopy (AFM). The growth event of COM crystals follows spiral growth mechanism and each surface, (100), (010), and (12-1) has hillocks with steps that can be assigned to specific crystal faces, enabling measurement of growth rates along specific crystallographic directions. When the anionic macrmolecules are added in supersaturated solution, the formation of growth hillocks on COM faces and advancement of steps are disturbed by roughening the ledges and narro! wing the steps width. The magnitude of this effect depends on the macromolecule structure and the macromolecule concentration. |
| 저자 |
정태성1, X. Sheng2, 김우식3, J.W. Wesson4, M.D. Ward2, 최창균1
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| 소속 |
1서울대, 2Univ. of Minnesota, 3경희대, 4Medical College of Wisconsin |
| 키워드 |
crystal growth |
| E-Mail |
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| 원문파일 |
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