| 초록 |
Indwelling urethral catheters(IUCs) are commonly used in home care and hospitalized patients to aid urination and relieve urethral retention. IUC insertion, however, often cause pain and discomfort to the patients. To alleviate pain, opioid and antimuscarinic drugs can be prescribed by oral administration or injection, but may cause systemic side effects. In this respect, local treatment of anesthetics can be a good alternative. In addition, as the IUCs placed in patients generally stay for 2-4 days, sustained drug delivery should also be considered. Therefore, we propose a urethral catheter capable of releasing drug locally for 7 days. To prepare drug releasing layer, poly(lactic-co-glycolic acid) (PLGA) and lidocaine were electrospayed. Fourier transform infrared (FTIR) spectrometry and X-ray diffractometer(XRD) were employed to analyze the layer. Also it was also confirmed up to 7 days of drug releasing in layered IUCs. The work is undergoing to assess in vivo safety and efficacy. |
