| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표15분) |
| 제목 |
Fast-curable tissue adhesives for corneal wound healing |
| 초록 |
As a promising alternative of conventional sutures, glue-type tissue adhesives for wound closure is gaining popularity. However, difficulty in controlling adhesion time and poor wet adhesion of existing tissue adhesives limit their practical use in the clinic. Herein, we report in situ hydrogel-forming tissue glues based on photocrosslinkable hyaluronic acid (HA), providing firm tissue adhesion under wet and dynamic conditions. Depending on the degree of photocrosslinkable groups in HA polymer chains, mechanical properties and adhesive performance were improved. In the rabbit corneal incision model, the HA glue quickly sealed the incision site following low-energy UV exposure for 5 seconds and showed uniform corneal wound healing compared to control groups. Considering high biocompatibility and drug-loading capacity of HA hydrogels, the fast-curable HA glue can be applied for diverse biomedical applications, requiring long-term tissue adhesion and sustained drug delivery. |
| 저자 |
이혜선, 양승윤, Ajeesh Chandrasekharan, 성금용, 조연지, 이종수
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| 소속 |
부산대 |
| 키워드 |
tissue adhesive; hyaluronic acid; biopolymer; wound healing
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| E-Mail |
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