| 초록 |
Superparamagnetic iron oxide nanoparticles (SPIONs), have been developed to visualize tumor lesion. However, therapeutic effect wasn’t enough to treat cancer, so there were needs to image and treat tumor simultaneously. Photosensitizer (PS) cause reactive oxygen species (ROS) under specific wavelength and can induce tumor cells death. PS and SPOINs have poor selectivity and low solubility; hence, we fabricated tumor-targetable and water-soluble magnetic nanoparticles (TWNPs) coated with vitamin-polyethylene glycol. The ligand-substitution was conducted with phenolic acid and confirmed by FT-IR spectroscopy. The selectivity of TWNPs was evaluated on various cell lines. Uniform size distribution was measured by DLS analysis and TEM images. CLSM and MRI were conducted to confirm imaging efficiency of TWNPs. In conclusion, newly formulated nanoparticles can be a promising theranostic agent for tumor theranostics. |
