| 초록 |
Sonodynamic therapy (SDT) is an emerging therapeutic modality that utilizes ultrasound (US) to focus exogenous energy on the deeply inherent tumor site. Besides, SDT has been proved to eradicate tumor directly with reactive oxygen species (ROS) triggered by US. Despite these promising effects, in vivo applications have been limited due to the lack of sonosensitizers. Herein, we developed a gas precursor encapsulated sonosensitizer to enhance cavitation to produce a larger amount of ROS. First, we prepared PEGylated mesoporous silica-titania nanoparticles (P-MSTNs) as a sonosensitizer, and loaded perfluorohexane (PFH) as a gas precursor. Under US irradiation, PFH@P-MSTNs generated high amount of ROS, effectively suppressing the tumor growth. Further, the vaporization of PFH exhibits a strong photoacoustic signal in vivo for up to 6h. Consequently, PFH@P-MSTNs mediated SDT showed a considerable therapeutic efficacy and a great potential for future cancer theranostics. |
