| 초록 |
In the past decades, nanomaterials that are responsive to light have revolutionized the field of cancer theranostics. However, light-responsive theranostics systems have shown limitations in application to the medical area such as damaging to normal tissue and low penetration depth. Nowadays, lanthanide-doped upconversion nanoparticles (UCNPs) which have strong upconversion luminescence (UCL), robust photostability, deep penetration in deep tissue and high signal-to-noise ratio have been intensively studied for near-infrared (NIR)-triggered photodynamic therapy (PDT). In this study, UCNPs composed of multi-shell structure were synthesized by thermal decomposition method. The surface modification of UCNPs was demonstrated for bioimaging and PDT applications. In addition, PDT effects of the UCNPs-based nanoplatform were investigated using two types of cancer cell lines. |
