| 학회 | 한국화학공학회 |
| 학술대회 | 2022년 봄 (04/20 ~ 04/23, 제주국제컨벤션센터) |
| 권호 | 28권 1호, p.1317 |
| 발표분야 | [주제 12] 화학공학일반(부문위원회 발표) |
| 제목 | Visualization of cholesterol crystal kinetics and removal: Implication for steatohepatitis and cholelithiasis |
| 초록 | Cholesterol is an essential component of cell membranes and performs critical roles in body. When body cholesterol level rises, crystallization starts, and these cholesterol crystals (CC) are the cause of several diseases such as steatohepatitis, and cholelithiasis. In this research, oil-water system is prepared to form crystals on interface and try to inhibit, remove them. Also, cholesterol derivatives such as ursodeoxycholic acid (UDCA), provitamin D3, and cholecalciferol, change the shape of the crystals or delayed crystallization. Comparing crystal size, shape, and density per area versus time, our result claims that cholesterol derivatives affect the kinetics of cholesterol crystallization. Based on the spectroscopic data and observation, we expect that prescribing cholesterol derivatives to patients suffering from cholesterol-related diseases may have a pharmacological effect. Keyword: Cholesterol, Crystallization, Cholecalciferol, Interface, Steatohepatitis |
| 저자 | 강승한1, 최시영2 |
| 소속 | 1한국과학기술원, 2카이스트 |
| 키워드 | 이동현상(Transport Phenomena) |
| 원문파일 | 초록 보기 |
