| 학회 | 한국화학공학회 |
| 학술대회 | 2022년 봄 (04/20 ~ 04/23, 제주국제컨벤션센터) |
| 권호 | 28권 1호, p.926 |
| 발표분야 | [주제 10] 헬스케어 |
| 제목 | Synthesis of gelatin micro-complex with GO/Cu for antibacterial effect in wound infections |
| 초록 | Wound infections are caused by the growth of bacteria inside the wound. If a wound infection progresses, wound healing may be delayed, and the wound may worsen, causing life-threatening complications such as sepsis. Treatment of wound infections involves treating the wound with an antibacterial materials. In this study, graphene oxide(GO)/copper nanocomposites was used. To reduce the cytotoxicity of the nanocomposite, we encapsulated GO/Cu with a gelatin complex. The catechol group bound to the gelatin create synergizes the adhesion through numerous interactions. In particular, we used gallic acid that it has anti-inflammatory and antibacterial properties. Gelatin and gallic acid were combined by using EDC/NHS as a crosslinker, and this was confirmed by FT-IR, 1H NMR, and fluorescence. As a result, it has been proven that it has an antibacterial effect against both Gram-positive bacteria and Gram-negative bacteria, even with a small amount and biocompatibility with human cells (HDF). The reported work has demonstrated the potential of antibacterial gelatin micro-complex to inhibit infectious bacteria with anti-inflammatory and biocompatible for cells. |
| 저자 | 김남주, 최종훈 |
| 소속 | 중앙대 |
| 키워드 | 생물화공(Biochemical Engineering) |
| 원문파일 | 초록 보기 |
